Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation
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چکیده
منابع مشابه
Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation.
Thalidomide is a potent teratogen that induces a range of birth defects, most commonly of the developing limbs. The mechanisms underpinning the teratogenic effects of thalidomide are unclear. Here we demonstrate that loss of immature blood vessels is the primary cause of thalidomide-induced teratogenesis and provide an explanation for its action at the cell biological level. Antiangiogenic but ...
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Of all congenital anomalies, limb reduction defects maintain a high profile with the public. In the early 1960s, high rates of limb reductions were associated with expectant mothers taking the drug thalidomide. As a result of this, congenital anomaly surveillance systems were established to try and prevent further such episodes. In the late 1980s limb reductions were found to be associated with...
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Abnormalities oflimbs have been seen occasionally at all times. Thalidomide-embryopathy, however, has produced special types of defects of the extremities, which in variety and above all in numbers has made necessary the provision of special centres for treatment. At the Dept. of Paediatric Surgery and Orthopaedics of the University Children's Hospital, Munich, we observed from January 1959 to ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2009
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0901505106